NU-CCNE Northwestern



























NU-CCNE researchers have access to an extensive array of equipment, facilities, and laboratories. partial list of available resources is given below:

integrated Molecular structure education and research center – provides access to most types of chemical analysis instrumentation. NMR spectrometers, mass spectrometers, optical spectrometers, elemental analysis instruments, chromatography instruments, thermal analysis equipment, and X-ray diffractometers are found in this lab.

BIOIstatistics CORE FACILITY – provides a full range of biostatistical and data management/data analysis support, including assistance with the development of protocols, the design of Phase I, II, and III clinical trials, sample size and power calculations, prognostic factor analysis, analysis of proteomic data, and other types of statistical analyses. (Cancer Center)

Cell Imaging Facility – provides access to fluorescence, confocal, and electron microscopy; microinjection and digitally controlled temperature stage for live cell observation; computerized image analysis and digital image manipulation; and the use of advanced imaging modes such as FREP and FRET. A satellite facility in a pathogen-free barrier facility houses Olympus small animal fluorescence and microprobe-based intravital fluorescence imaging systems. Both Nikon and Leica use this facility to test their latest instruments.(Cancer Center)

Clinical Research Office– manages all aspects of NU oncology trials. (Cancer Center)

DND-CAT (DuPont-Northwestern-Dow Collaborative Access Team) – is a permanent synchrotron research center at the Advanced Photon Source, a third-generation synchrotron source of x-ray radiation located at Argonne National Laboratory, 20 miles southwest of downtown Chicago. DND-CAT operates two beamlines: an undulator beamline of exceptional brilliance and a bending magnet beamline that can support up to three simultaneous experiments. DND-CAT is supported through E. I. duPont de Nemours & Co., Northwestern University, The Dow Chemical Co., the State of Illinois through the Department of Commerce and the Board of Education (HECA), the US Department of Energy, Office of Energy Research, and the US National Science Foundation Division of Materials Research.

Electron Probe Instrumentation Center – houses one of the most complete arsenals of routine and state-of-the-art electron microscopes in the world. (McCormick School of Engineering)

Flow Cytometry Facility – Provides cell sorting services and access to routine flow cytometry assays such as immunophenotyping and DNA analysis as well as guidance, technical assistance and equipment for investigators to utilize more complex multi-parametric, multi-laser measurement and cell sorting.(Cancer Center)

Institute for Bio-Nanotechnology in Medicine (IBnAM) Clean Room Core Facility – Designed for interdisciplinary research at the interface of physical and biological sciences. The facility encompasses 1,290 sq feet including a 10,000 sq ft lab and two classrooms. The facility includes a fully functional photolithography line and a cell culture area.

J.B. Cohen X-Ray Diffraction Facility – includes 10 standard X-ray generators, four rotating anode units, and a variety of goniometers. Also available are three small-angle units, an EXAFS unit, topographic units, and equipment for work with single crystals or powders (from 2 K to 2,500 K). (McCormick School of Engineering)

Keck Biophysics Facility – provides a wide array of sophisticated spectroscopy equipment and analytical instruments which are available for investigator use, along with the necessary training. (Cancer Center)

Keck Interdisciplinary Surface Science Center – facilitates research, collaboration, education, and outreach in all science from soft biological matter to hard physical matter, specializing in surface analysis and nanoscale characterization. (McCormick School of Engineering)

Monoclonal Antibody Facility – provides technology for the efficient creation of hybridoma cell lines and the production of monoclonal antibodies from these cell lines. Services include immunization of animals, somatic cell fusions, cloning and screening of hybridomas, subcloning and establishment of antibody producing cell lines, and production of active antibodies from hybridoma lines. (Cancer Center)

Mouse Phenotyping Core Laboratory provides histopathology expertise and a comprehensive array of research histology services and assists with the analysis of morphological phenotypes of newly developed mouse models. The lab also provides pathologist expertise for interpreting and reporting histopathological findings, and training in the gross and microscopic analysis of animal models. (Cancer Center)

Nanoscale Imaging, Fabrication, Testing and Instrumentation (NIFTI) Facility – is a multi-user, multi-purpose, open-access facility that provides state-of-the-art surface science characterization tools and soft lithographic writing, imaging, and analysis capabilities.The facility houses several scanning probe microscopes specifically geared to nanoscale characterization, nanopatterning, and lithography, and a near-field scanning optical microscope with tunable femto-second laser source.

NUFAB – provides equipment for characterization, deposition, etching, and photolithography at the nanoscale.

Outcomes Measurement Core – provides consultation and support for research that involves collecting, analyzing or interpreting self-report data (Cancer Center)

Pathology Core Facility – provides tissue analysis and tissue procurement services, including routine research histology and immunohistochemistry as well as more specialized techniques such as in situ hybridization, cytogenetics, laser capture microdissection and tissue microarrays. Tissue procurement services include acquisition of archived biological materials or prospective procurement and appropriate processing and storage of fresh tissue or fluid. (Cancer Center)

Structural Biology Core Facility – provides essential support for researchers studying the relationship between macromolecular structure and function or who are using protein structure as the starting point for structure-based drug discovery. The facility provides resources required for the crystallization of macromolecules and crystallographic structure determiniation, refinement, and analysis; molecular graphics and computational support for sturctural biology, and structure-based drug design, and highly specialized resources for macromolecular charaterization related to structural biology.

Transgenic and Targeted Mutagenesis Core Facility – generates transgenic mice (by pronuclear injection of investigator provided DNA) and provides all services required to generate knock-out (or knock-in) mice, from targeting of ES cells through the generation of the germline competent chimeric mice. Conditional gene targeting strategies utilizing Cre/loxP and Flp/FRTrecombinase systems can be implemented. (Cancer Center)

Animal Models and Small Animal Imaging – An array of state-of-the-art instruments for whole animal imaging and for the imaging of excised tissues are located at various sites on the Northwestern University campus. Facilities for sophisticated microscopy and image analysis of tissue sections are located in the Biological Imaging Facility on the Evanston campus, and the Cell Imaging Facility on the Chicago campus. The NU Center for Comparative Medicine provides a small animal fluorescence and a microprobe-based intravital fluorescence imaging system. The NU Department of Radiology 's Center for Advanced Magnetic Resonance Imaging houses 1.5 and 3 Tesla Siemens MR scanners devoted exclusively to research, and an Interventional Radiology Research Laboratory equipped for X-ray-digital subtraction angiography. A recent $2 million grant from the NIH allowed the purchase of a 7 Tesla MRI scanner that provides high-resolution in vivo anatomic and functional MR scanning of small rodents. The Center for Advanced Molecular Imaging on the Evanston campus occupies 10,000 sq ft and houses over $15 million worth of instrumentation.

Chicago Biomedical Consortium/Lever AwardThe Chicago Biomedical Corsortium (CBC) has provided a >$2 million Lever Award to the NU-CCNE to support the establishment of two core facilities that will produce and distribute, to a broad group of CBC-affiliated researchers, well-defined matrices and substrates for culturing cancer cells.

Center of Cancer Nanotechnology Excellence Northwestern University | 2145 Sheridan Road, K111 | Evanston, IL 60208
Tel: (847) 467-5335 | Fax: (847) 491-3721
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Last updated 01/23/12 |World Wide Web Disclaimer | Policy Statement | ©2007 Northwestern University
  This work is supported by the Center of Cancer Nanotechnology Excellence (CCNE) initiative of the National Institutes of Health's National Cancer Institute under Award Number 1-U54CA151880-01. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s)and do not necessarily reflect those of the National Institutes of Health.